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《医学前沿（英文）》 2012年 第6卷 第3期 页码 288-295 doi: 10.1007/s11684-012-0208-4
Tramadol is a potent analgesic. However, the analgesia efficacy of tramadol, particularly its minimum effective dose (MED), is not clear. The aim of this study is to find MED of tramadol for postoperative analgesia in infants. The continual reassessment method (CRM) was performed to find MED. Infants undergoing surgeries were included in the 3 phases of this series. In each phase, 24 participants were allocated a different tramadol dose. Pain intensity was measured by face, legs, activity, cry, consolability (FLACC) measurement at 3-hour intervals. Tramadol was considered ineffective if the FLACC score was higher than 4 in 10 at anytime. In phase 1, seven dose levels were used within the range 0.1–0.4 mg?kg-1·h-1. Phase 1 was insufficient to identify the MED, and we increased the dose to 0.4–0.8 mg?kg-1·h-1 in phase 2. Phase 2 was insufficient to identify the MED. In phase 3, local anesthetic wound infiltration was introduced, and the tramadol dose levels tested were the same as in phase 1. The successful analgesia probability of tramadol 0.4 mg?kg-1?h-1 was 82.1% (95% CI, 0.742–0.925) in phase 1. In phase 2, it was 84.7% (95% CI, 0.789–0.991) with the dose 0.8 mg?kg-1?h-1. Phase 1 and phase 2 were insufficient to identify the MED. In phase 3, the successful analgesia probability for dose 0.35 mg?kg-1?h-1was 96.7% (95% CI, 0.853–0.997).We have demonstrated that tramadol provides insufficient analgesia for surgeries considered to cause moderate-to-severe postoperative pain in infants if used as the sole analgesic, and that local anesthetic wound infiltration enhances the efficacy of tramadol.
关键词： tramadol minimum effective dose postoperative analgesia infants continual reassessment method
Efficacy and safety of perioperative parecoxib for acute postoperative pain treatment in children: a
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《医学前沿（英文）》 2015年 第9卷 第4期 页码 496-507 doi: 10.1007/s11684-015-0414-y
Perioperative parecoxib administration reduces postoperative pain, opioid consumption, and adverse events in adult patients. However, the efficacy and safety of parecoxib in children remain unclear. This meta-analysis included related published studies to address this concern. Eight databases in the literature until February 2015 were systematically explored to identify randomized controlled trials (RCTs) comparing perioperative parecoxib administration and placebo/standard treatments for acute postoperative pain in children. Primary outcomes were postoperative pain scores and adverse events. The Face, Legs, Activity, Crying, Consolability scale was used to score pain in children younger than 6 years, whereas the Visual Analog Scale was used in children older than 6 years. Secondary outcomes were sedation scores (measured using the Ramsay scale), agitation scores (measured using the Sedation-Agitation Scale), and opioid consumption. The methodological quality of RCTs was independently assessed in accordance with the “Risk of bias” of Cochrane Collaboration. Data were analyzed using Review Manager 5.2. Twelve RCTs involving 994 patients met the inclusion criteria. Compared with children who received placebo treatment, those who received parecoxib demonstrated lower early (2 h) and later (12 h) postoperative pain scores; lower incidence rates of postoperative nausea, vomiting, and agitation; higher early (1 h) postoperative sedation scores; and lower agitation scores. Similarly, children who received parecoxib had lower early (2 h) and later (12 h) postoperative pain scores, lower incidence rates of postoperative nausea and vomiting, and lower early (1 h) postoperative sedation scores compared with those who received standard treatments; however, these children showed no significant difference in agitation scores. Unfortunately, data on the effect of parecoxib on opioid consumption were insufficient. Overall, these results suggested that perioperative parecoxib administration was associated with less acute postoperative pain and fewer adverse events compared with placebo or standard treatments. Parecoxib administration also resulted in less emergence agitation compared with placebo treatment and less excessive sedation concern compared with standard treatments. However, the long-term effects, effects on opioid consumption, and patient satisfaction of parecoxib administration warrant further investigation.
关键词： NSAID cyclooxygenase 2 inhibitor child pain postoperative opioid placebo
Pei-Tu REN BM, Bao-Chun LU MM, Zhi-Liang CHEN MM, Hong FU MM,
《医学前沿（英文）》 2010年 第4卷 第1期 页码 77-81 doi: 10.1007/s11684-010-0005-x
关键词： biliary disease cardiopulmonary complication stair-climbing test
钟慧玲
《中国工程科学》 2014年 第16卷 第5期 页码 31-33
文本研究人流后关爱（PAC）在人工流产术后计划生育关爱中的应用。选择2011年1月—2013年1月，武汉市蔡甸区计划生育服务站门诊进行人工流产的260 名病例为分析对象，根据其先后序号按照奇偶顺序分为关爱PAC组和对照组，每组130 例，对PAC组进行流产后关爱指导，而对照组只进行常规处理。一年后，共收回有效问卷248 份，其中关爱组126 份，对照组122 份。PAC组避孕知识和人流后保健知识掌握优良率均高于对照组，生活质量评分有明显优势，而重复流产率明显较低，育龄妇女满意率较高。其差异均有统计学意义（P<0.05）。高价值的PAC关爱，对于减少重复流产的概率和提高生活质量有着积极重要的意义。
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《医学前沿（英文）》 2016年 第10卷 第4期 页码 465-472 doi: 10.1007/s11684-016-0482-7
Previous studies have demonstrated the effects of different afferent fibers on electroacupuncture (EA)-induced analgesia. However, contributions of functional receptors expressed on afferent fibers to the EA analgesia remain unclear. This study investigates the roles of acid-sensing ion channel 3 (ASIC3) and transient receptor potential vanilloid 1 (TRPV1) receptors in EA-induced segmental and systemic analgesia. Effects of EA at acupoint ST36 with different intensities on the C-fiber reflex and mechanical and thermal pain thresholds were measured among the ASIC3−/−, TRPV1−/−, and C57BL/6 mice. Compared with C57BL/6 mice, the ipsilateral inhibition of EA with 0.8 C-fiber threshold (0.8Tc) intensity on C-fiber reflex was markedly reduced in ASIC3−/− mice, whereas the bilateral inhibition of 1.0 and 2.0Tc EA was significantly decreased in TRPV1−/− mice. The segmental increase in pain thresholds induced by 0.3 mA EA was significantly reduced in ASIC3−/− mice, whereas the systemic enhancement of 1.0 mA EA was markedly decreased in TRPV1−/− mice. Thus, segmental analgesia of EA with lower intensity is partially mediated by ASIC3 receptor on Aβ-fiber, whereas systemic analgesia induced by EA with higher intensity is more likely induced by TRPV1 receptor on Ad- and C-fibers.
关键词： electroacupuncture analgesia ASIC3 TRPV1 C-fiber reflex
李川海,马明福,杨皓,周署平
《中国工程科学》 2014年 第16卷 第5期 页码 110-112
2012—2013年根据国家卫生和计划生育委员会发布的《计划生育手术并发症鉴定管理办法（试行）》和《计划生育手术并发症鉴定分级标准（试行）》，通过填写重庆市统一的计划生育手术并发症鉴定申请表，对重庆市部分区（县）进行了计划生育手术并发症鉴定，并对市级鉴定情况进行了探讨。结果表明：2012—2013 年申请男性绝育术后并发症市级鉴定的56 例中，符合男性绝育术后并发症的有10 例，占申请人数的25.2 %；自述症状中有25 例与男性绝育术后并发症无关，占44.64 %；符合男性绝育术后并发症的都是20 世纪90 年代以前进行的绝育术。因此，男性绝育术后并发症鉴定应严格执行鉴定标准，做到公平、公开、公正，应做好男性绝育术相关知识的宣传，加强对老年病科普知识的宣传，并加强计划生育技术服务队伍的建设。
标题 作者 时间 类型 操作
Estimation of the minimum effective dose of tramadol for postoperative analgesia in infants using the
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期刊论文
Efficacy and safety of perioperative parecoxib for acute postoperative pain treatment in children: a
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期刊论文
Role of stair-climbing test in predicting postoperative cardiopulmonary complications in elderly patients
Pei-Tu REN BM, Bao-Chun LU MM, Zhi-Liang CHEN MM, Hong FU MM,
期刊论文
Distinct roles of ASIC3 and TRPV1 receptors in electroacupuncture-induced segmental and systemic analgesia
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期刊论文
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